Understanding the Pandemic

Paperback

Chatterjee, Shampa , Duarte Neto, Amaro Nunes , Cascella, Marco 저자(글)

Academic Press · 2024년 11월 08일

책 소개

작가정보

저자(글) Chatterjee, Shampa

Shampa Chatterjee is Associate Professor at the Department of Physiology, University of Pennsylvania School of Medicinein Philadelphia. Trained in India, Germany and the US, her current research is on inflammation-immune signaling with a focus on the vascular system. Her lab studies the role of redox signals in the onset and amplification of inflammation and immune responses. Toward this, recent work from her group showed that the systemic cytokine storm associated with COVID-19 activates an inflammation cascade in the vascular system that can potentially lead to vascular dysfunction. Research in her lab is funded by extramural research funding from the NIH and corporate sources. Dr. Chatterjee serves on the Editorial Board of several journals in the field of pulmonary physiology. She has published more than 100 papers in peer reviewed journals and edited two books on Endothelial Signaling, and on Inflammation and Immune responses. Dr. Chatterjee has received numerous awards such as the Caroline Tum Suden young Investigator Award, and the Hermann Rahn award for Excellence if Pulmonary Physiology. The topics addressed in this book are central to her research where she tries unraveling the balance between the onset of inflammation in host protection and resolution of inflammation in host injury.

저자(글) Duarte Neto, Amaro Nunes

Amaro Nunes Duarte Neto is an infectious diseases physician and pathologist, and Associate Professor at the Department of Pathology, Faculty of Medicine, University of São Paulo (FMUSP). After graduating in medicine from the Universidade de Pernambuco in 1999, he moved to São Paulo, in the south-east of Brazil, to complete a fellowship in internal medicine and infectious diseases at the Hospital das ClInicas-FMUSP from 2000 to 2004. He also worked in the Intensive Care and Emergency Department at the University of São Paulo. After obtaining his PhD. in the field of leptospirosis pathology, he studied anatomical pathology and completed residency at the A.C. Camargo Cancer Centre in São Paulo from 2011-2014. Since then, he has been involved in autopsy and infectious disease pathology, with numerous publications on the pathology of COVID-19, yellow fever, AIDS, tuberculosis, and fungal infections. He is currently leading a project on preparedness in anatomical pathology for rapid response to future epidemics in the city of São Paulo, Brazil.

저자(글) Cascella, Marco

Marco Cascella, MD, is an Associate Professor of Anesthesia, Intensive Care, and Pain Medicine at the University of Salerno. He graduated with honors in Medicine and Surgery in 1997 from the University "Vanvitelli" of Naples and later pursued postgraduate studies in anesthesia and intensive care in 2001. Prof. Cascella is actively engaged in research, with a particular focus on automatic pain assessment using AI techniques. He serves as an editorial board member for several medical journals and has delivered lectures at numerous conferences and conventions. With an extensive academic background, he has authored approximately 250 scientific publications, books, book chapters, etc., covering various medical domains ranging from anesthesia, pain treatment, and oncology to palliative care. Prof. Cascella plays a leadership role and actively participates in various research projects, showcasing his commitment to advancing medical knowledge and technology.

목차

• Section 1: coronaviruses (incl SARS-CoV and MERS), the structure (sequence), mechanism of action 1. Origin of SARS-CoV-2 2. SARS-CoV-2: Insights into the genome structure 3. Mechanism of binding and infection: Role of the Spike Glycoprotein 4. ACE2 in SARS-CoV-2 infectivity 5. Population-Specific Polymorphisms and SARS-CoV-2 Infectivity 6. SARS-CoV-2, SARS-CoV, and MERS-COV: similarities and differences in origin and transmission Section 2: Immune Response to COVID-19 and its effects on various organs 7. Characterization of the immune response with viral attack 8. Immune Responses and COVID-19 severity 9. Seroconversion and Adaptive Immunity to COVID-19 10. Organ specific immune related changes with COVID-19 11. Blocking immune pathways in COVID-19 12. Immune Response in Fatal COVID-19 Section 3: ?Clinical manifestations” based on reports from clinical observations and postmortem studies 13. Postmortem Examination of COVID-19 Lungs and Heart 14. Renal Histopathological Analysis Kidney 15. Postmortem Neuropathology in COVID-19 16. Microcirculation Section 4: The blood vessels and COVID-19: Vascular dysfunction, coagulopathies 17. Vascular manifestations of COVID-19: endothelial dysfunction and damage 18. Vasculitis and proinflammatory cascades with COVID-19 19. D-dimer in systemic circulation and COVID-19 outcome 20. Hypercoagulability in COVID-19 Section 5: Neuro-COVID-19 and its long-term implications 21. COVID and the nervous system: Mechanisms and Consequences 22. Neuroinflammation with COVID-19: single cell and model studies 23. Neurologic and Psychiatric outcome in survivors Section 6: Should COVID-19 concern nephrologists? Why and to what extent?" 24. Mechanisms that drive in acute kidney injury with COVID-19 25. Models and cellular monolayers to study effect of SARS-CoV-2 on kidney 26. Renal Manifestations of COVID-19 in the Clinic Section 7: Long COVID-19 (long term effects summarizing of clinical reports in literature) 27. Long COVID or post-acute sequalae of COVID: An introduction 28. Mechanisms and Risk factors 29. Characterizing Long COVID-19: Lessons in the clinic 30. Risk factors and Management Section 8: The vaccines 31. COVID-19: The vaccine development strategies 32. mRNA vaccines: The new frontier 33. Safety and Efficacy: A comprehensive review Section 9: Public health handling (lessons from the US, EU, Brazil, China, India etc.) 34. US 35. EU 36. Brazil 37. China 38. India Section 10: From the Editors? desk 39. The COVID-10 pandemic: Lessons Learnt 40. Current and Future Perspectives

기본정보

ISBN	9780443191701 ( 0443191700 )
발행(출시)일자	2024년 11월 08일
쪽수	950쪽
크기	191 * 235 * 45 mm / 1932 g
언어	영어